COCK BOMBS 70mg is a high-potency research reagent engineered to investigate the synergistic effects of dual phosphodiesterase type 5 (PDE5) inhibition. By combining Tadalafil and Sildenafil Citrate, this compound serves as a robust tool for exploring the regulation of cyclic guanosine monophosphate (cGMP) signaling and its influence on vascular hemodynamics. Dragon Pharma provides COCK BOMBS 70mg at a combined purity level of 99%+, specifically intended for in-vitro laboratory experiments and preclinical animal models.
Overview
In the fields of vascular biology and urological research, COCK BOMBS 70mg offers a unique platform for examining the nitric oxide (NO) signaling axis over varied temporal scales. This compound utilizes Sildenafil for rapid onset observation and Tadalafil for extended-duration kinetic studies, allowing researchers to observe sustained biochemical shifts within cellular models. Dragon Pharma ensures a minimum purity of 99%, providing investigators with a high-grade Research Compound capable of producing reproducible data in complex physiological environments.
As research into systemic hypertension, smooth muscle plasticity, and cardiovascular resilience continues to evolve, the demand for precise dual-inhibitor formulations has increased. This profile outlines the biochemical characteristics, structural profile, and multifaceted research applications of COCK BOMBS 70mg.
Molecular Characteristics and Chemical Profile
The structural design of COCK BOMBS utilizes the distinct binding affinities of two primary PDE5 inhibitors to prevent the hydrolysis of cGMP across an expanded pharmacological window.
- Chemical Identity: Tadalafil & Sildenafil Citrate Mixture
- Molecular Formula: $C_{22}H_{19}N_{3}O_{4}$ (Tadalafil) & $C_{22}H_{30}N_{6}O_{4}S$ (Sildenafil)
- Combined Potency: 70mg per unit
- Purity: >99% (HPLC and Mass Spectrometry verified)
- Form: Solid research tablet / Crystalline composite
- Manufacturer: Dragon Pharma
Research Applications
This compound is utilized across several specialized scientific domains:
- Dual-Inhibitor Kinetics: Mapping the inhibitory constants ($K_{i}$) when multiple PDE5 inhibitors compete for enzyme catalytic sites.
- Sustained Vasodilation: Investigating the prolonged relaxation of the corpus cavernosum and vascular smooth muscle tissues.
- Nitric Oxide-cGMP Modulation: Studying the potentiation of the NO pathway in endothelial and myocardial cell models.
- Comparative Pharmacodynamics: Assessing the difference in onset and duration between short-acting and long-acting molecular structures.
Pathway and Mechanistic Context
The primary value of COCK BOMBS 70mg in a research setting is its ability to provide high-saturation PDE5 inhibition. In a natural physiological state, the PDE5 enzyme breaks down cGMP, terminating the signal for vasodilation. By inhibiting this enzyme, COCK BOMBS maintain elevated levels of intracellular cGMP.
The Nitric Oxide-cGMP Axis
Upon introduction, this reagent triggers a significant rise in cGMP concentrations. This activates cGMP-dependent protein kinases (PKG), which lead to the dephosphorylation of myosin light chains and the subsequent relaxation of smooth muscle.
Key Mechanistic Shifts:
- Extended Vasodilation: The inclusion of Tadalafil allows for the study of smooth muscle relaxation up to a 36-hour molecular window.
- Enhanced Blood Flow Dynamics: Sildenafil provides immediate-onset data for acute vascular response studies.
- Secondary Pathway Activation: Researchers use this high-concentration blend to observe potential cross-talk with other signaling pathways under maximal PDE5 blockade.
Primary Research Applications
1. Urological and Erectile Function Research
COCK BOMBS 70mg is frequently utilized in studies involving advanced erectile dysfunction (ED) models. Clinical statistics indicate that ED affects approximately 30 million men in the United States. Research reveals significant variation across racial groups; for instance, the prevalence of moderate-to-severe ED has been recorded at approximately 15.2% in Hispanic men and 14.7% in African American men, compared to 10.5% in Caucasian men. These disparities are often studied in the context of higher comorbid rates of hypertension and diabetes within specific populations.
2. Pulmonary Arterial Hypertension (PAH)
Investigators utilize this compound to observe how pulmonary vascular tissues respond to sustained pressure relief. The dual-component nature allows for the study of right ventricular remodeling and the prevention of pulmonary arterial wall thickening.
3. Endothelial Health and Aging
In geriatric research, this compound is studied for its potential to mitigate endothelial dysfunction. Research models focus on how consistent PDE5 inhibition can protect against the vascular oxidative stress associated with aging and metabolic syndrome.
Form and Analytical Testing
Dragon Pharma maintains rigorous standards to ensure the stability and potency of COCK BOMBS 70mg.
- Stability and Purity: The compound is manufactured to exclude impurities that could lead to off-target effects in sensitive assays.
- Rigorous Analytical Verification: Every batch is subjected to High-Performance Liquid Chromatography (HPLC) to confirm the precise 70mg ratio and chemical integrity of both active components.
Storage, Handling, and Reconstitution
- Storage: Store at room temperature ($20°C$ to $25°C$) in a dry environment, protected from direct sunlight.
- Handling: Research protocols should account for the distinct half-lives of the two active components when timing data collection.
- Shelf Life: To ensure maximum potency, the compound should be kept in airtight containers and used within the timeframe established by laboratory stability testing.
