CJC-1295 DAC 5mg

CJC-1295 with DAC by Dragon Pharma is a synthetic 29-amino acid peptide analog of Growth Hormone-Releasing Hormone (GHRH). As a functional analog, it is the shortest truncated peptide capable of stimulating the pituitary gland's somatotroph cells to trigger the release of endogenous growth hormone (GH).

What distinguishes Dragon Pharma's CJC-1295 DAC from standard GHRH analogs is its modified structure featuring four specific amino acid substitutions and the integration of the Drug Affinity Complex (DAC). This biochemical addition allows the peptide to bind to plasma proteins (specifically albumin), significantly extending its half-life to approximately 8 days.

Product Specifications

• Brand: Dragon Pharma
• Molecular Formula: C165H269N47O46
• Molecular Weight: 3367.95 g/mol
• Purity: >99% (HPLC/MS Verified)
• Format: Lyophilized White Powder
• Scientific Category: ACC
• Regulatory Status: Research Use Only (RUO)

Primary Research Applications

Scientific investigations into CJC-1295 DAC focus on its ability to maintain pulsatile growth hormone secretion while elevating baseline IGF-1 levels. Research suggests potential benefits in the following areas:

• Metabolic Enhancement: Studies indicate a potential for lipid metabolism, specifically utilizing adipose tissue for energy.
• Anabolic Potential: Theoretical promotion of protein synthesis and cellular proliferation, leading to improved muscle tissue hypertrophy.
• Bone and Tissue Density: Research explores its role in increasing bone mineral density and strengthening connective tissues.
• Sleep Regulation: Preliminary data suggests GHRH analogs may support the central nervous system's sleep-wake cycles and deep sleep duration.

Mechanism of Action

CJC-1295 DAC functions by mimicking the body's natural GHRH. Upon administration in laboratory models, it binds to GHRH receptors, activating G-proteins that stimulate the production of cyclic adenosine monophosphate (cAMP). This signaling cascade triggers the transcription of growth hormone genes.

Because of the DAC component, this peptide avoids the rapid 7-minute degradation seen in natural GHRH. Clinical data has shown that a single application can increase mean GH secretion by up to 50% and raise IGF-1 levels for 9 to 11 days, with cumulative effects observed upon repeated exposure.

Stability and Comparative Structure

While standard GHRH (1-29) fragments are highly susceptible to the enzyme dipeptidyl peptidase-4, Dragon Pharma ensures a high-stability profile through specific substitutions (D-Alanine at the 2nd position, Glutamine at the 8th, Alanine at the 15th, and Leucine at the 27th) to bolster enzymatic resistance and prevent oxidation.

Technical Handling & Storage Guidelines

• Long-Term Storage (Lyophilized): Stable for up to 2 years from the date of purchase when stored as supplied.
• Reconstituted Stability: Solutions in distilled water or DMSO may be stored at -20°C for up to 3 months.
• Thermal Management: * Shipping: Dispatched at -20°C to ensure stability.
• Critical Warning: Avoid repeated freeze/thaw cycles, as this can lead to peptide degradatio

Disclaimer: All products from Dragon Pharma are sold for research, laboratory, and analytical purposes only. CJC-1295 DAC is not intended for human consumption or diagnostic use. Please ensure compliance with local regulations and our Terms of Service.

Author:

All information was searched/edited by Dr. S. Edwin, and Dr. E. Croft who holds a doctorate from Case Western Reserve University School of Medicine

Refference:

https://en.wikipedia.org/wiki/CJC-1295