MOTS-c 10mg

for: Mitochondria; Energy; Weight loss & Insulin Resistance.

MOTS-c (10mg) is a specialized research mitochondrial-derived peptide (MDP) utilized primarily to investigate cellular metabolic homeostasis, insulin sensitivity, and mitochondrial-nuclear communication. As a 16-amino acid peptide encoded by the mitochondrial genome, it is a potent regulator of metabolic flexibility. Dragon Pharma provides MOTS-c 10mg at a purity level of 99%+, specifically for use in in-vitro laboratory experiments and preclinical animal models.

Overview

In the realm of metabolic research and mitochondrial biology, MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA type-c) has become a fundamental tool for investigators exploring the retrograde signaling pathways of the cell. Known scientifically as a mitochondrial-derived hormone, this peptide is a key mediator of the "mitochondrial-to-nucleus" stress response. Dragon Pharma provides MOTS-c 10mg at a minimum purity of 99%, ensuring that researchers have access to a high-grade Research Peptide capable of producing reproducible and accurate data in complex metabolic models.

As scientific inquiry into age-related metabolic decline, Type 2 Diabetes, and physical performance adaptation expands, the need for reliable mitochondrial signaling agents like MOTS-c has grown. This expanded profile examines the biochemical characteristics, structural integrity, and multifaceted research applications of MOTS-c 10mg.

Molecular Characteristics and Chemical Profile

The structural integrity of MOTS-c allows it to translocate from the mitochondria to the nucleus in response to metabolic stress. Once inside the nuclear environment, it regulates the expression of genes involved in antioxidant response and glucose metabolism.

• Chemical Identity: Mitochondrial-derived peptide MOTS-c
• Molecular Formula: C101H152N28O22S2
• Molecular Weight: 2174.62 g/mol
• Purity: >99% (HPLC and Mass Spectrometry verified)
• Form: Lyophilized powder
• Manufacturer: Dragon Pharma

Source: Wikipedia

Research Applications

The peptide is utilized in various scientific investigative domains, including:

• Mitochondrial Signaling: Mapping retrograde pathways between the mitochondria and the cell nucleus.
• Glucose Homeostasis: Investigating insulin-independent glucose uptake and GLUT-4 translocation.
• Lipid Metabolism: Studying the modulation of fatty acid oxidation and lipid accumulation in hepatic models.
• Cellular Aging: Assessing the role of MDPs in preventing cellular senescence and promoting longevity.
• Physical Adaptation: Evaluating mitochondrial biogenesis and adaptive responses to perceived physical strain.

Pathway and Mechanistic Context

The core value of MOTS-c 10mg in a laboratory setting is its ability to manipulate the AMPK signaling pathway and folate metabolism. In a natural physiological state, MOTS-c is released during metabolic stress to restore energy balance by inhibiting the folate cycle and increasing de novo purine synthesis.

The MOTS-c/AMPK Axis

Upon activation by metabolic shifts, MOTS-c promotes energy-producing catabolic pathways. One of the most significant downstream effects of this signaling is the activation of AMPK, which enhances fatty acid oxidation and improves cellular insulin sensitivity.

Key Mechanistic Shifts:

• Glucose Transport: MOTS-c facilitates glucose uptake in skeletal muscle models by enhancing the AMPK-GLUT4 axis.
• Lipid Metabolism: It targets the AICAR-like pathway to inhibit lipid synthesis while accelerating the "burning" of fat stores.
• Mitochondrial Protection: It promotes the expression of cytoprotective genes, enhancing the cell's resilience against oxidative damage.

Primary Research Applications

1. Metabolic Syndrome and Insulin Resistance

MOTS-c is heavily utilized in studies involving diet-induced obesity and metabolic dysfunction. Because it restores glucose homeostasis independently of the canonical insulin pathway, it provides a unique framework for investigating treatments for insulin-insensitive tissues.

2. Exercise Mimicry and Longevity

Known in research circles as an "exercise mimetic," MOTS-c is used to observe how tissues adapt to metabolic demands. Investigators study changes in mitochondrial density and the reversal of age-related physical decline in murine models.

3. Osteoporosis and Bone Health

In bone research, MOTS-c is studied for its "anti-osteoporotic" effects. Research models focusing on osteoblasts examine how MOTS-c promotes cell differentiation and mineralization through the TGF-beta signaling pathway.

Form and Analytical Testing

At Dragon Pharma, the commitment to scientific accuracy begins with a rigorous manufacturing process. MOTS-c 10mg is produced under strict laboratory conditions to ensure the compound remains stable and bioactive.

• Lyophilization for Stability: The compound is supplied in a lyophilized (freeze-dried) form. This process preserves the molecular structure, making it resistant to temperature fluctuations during transit.
• Rigorous Analytical Verification: Every batch undergoes High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to verify that the purity level is 99% or higher and the chemical signature matches the verified MOTS-c profile.

Author:

All information was searched/edited by Dr. S. Edwin, and Dr. E. Croft who holds a doctorate from Case Western Reserve University School of Medicine