IGF-1 LR3 1mg

for: Promotes Muscle and Cell Growth & Enhances Fat Metabolism.

IGF-1 LR3 (Long Arginine 3-Insulin-like Growth Factor-I) is a specialized research protein utilized primarily to investigate cellular proliferation, hyperplasia, and anabolic signaling pathways. As a synthetic analog of endogenous IGF-1, it is a potent activator of the IGF-1 Receptor (IGF-1R). Dragon Pharma provides IGF-1 LR3 1mg at a purity level of 99%+, specifically for use in in-vitro laboratory experiments and preclinical animal models.

Overview

In the realm of regenerative medicine and molecular biology, few compounds offer as much utility as IGF-1 LR3. This compound is a modified version of the natural IGF-1 protein, featuring an arginine substitution at the 3rd position and a 13-amino acid extension at the N-terminus. These modifications have made it a fundamental tool for investigators exploring muscle hypertrophy and cellular longevity. Dragon Pharma provides IGF-1 LR3 1mg at a minimum purity of 99%, ensuring that researchers have access to a high-grade Research Peptide capable of producing reproducible and accurate data in complex biological models.

As scientific inquiry into metabolic disorders, sarcopenia, and tissue engineering expands, the need for stable IGF-1 analogs has grown. This expanded profile examines the biochemical characteristics, structural integrity, and multifaceted research applications of IGF-1 LR3 1mg.

Molecular Characteristics and Chemical Profile

The structural integrity of IGF-1 LR3 is what allows it to bypass the inhibitory effects of IGF-Binding Proteins (IGFBPs). In its natural state, IGF-1 is quickly neutralized by these proteins; however, the "LR3" modification reduces binding affinity by over 1,000-fold, significantly increasing the peptide's bioavailability and half-life in research models.

• Chemical Identity: Long R3 Insulin-like Growth Factor-I
• Molecular Formula: C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉
• Molecular Weight: 9111.6 g/mol
• Purity: >99% (HPLC and Mass Spectrometry verified)
• Form: Lyophilized powder
• Manufacturer: Dragon Pharma

Source: PubChem

Research Applications

The peptide is utilized in various scientific investigative domains, including:

• Myogenesis: Mapping the pathways of satellite cell activation and muscle fiber hyperplasia.
• Glucose Transport: Investigating IGF-mediated glucose uptake in skeletal muscle models.
• Neuroprotection: Studying the modulation of neuronal survival and axonal growth.
• Osteogenesis: Assessing the impact of IGF signaling on bone mineral density and osteoblast proliferation.
• Cell Culture Enhancement: Utilizing the peptide as a high-potency supplement in serum-free media for industrial cell production.

Pathway and Mechanistic Context

The core value of IGF-1 LR3 1mg in a laboratory setting is its ability to manipulate the PI3K/Akt signaling pathway with sustained intensity. Unlike native IGF-1, which has a half-life of roughly 20 minutes, IGF-1 LR3 remains active in experimental environments for 20–30 hours.

The Akt-mTOR Signaling Axis

Upon binding to the IGF-1R, IGF-1 LR3 initiates a cascade of phosphorylation events. It promotes energy-consuming anabolic pathways while simultaneously inhibiting apoptotic (cell death) pathways. One of the most significant downstream effects of this activation is the upregulation of mTOR, a master regulator of protein synthesis.

Key Mechanistic Shifts:

• Hyperplasia: Unlike most anabolic agents that only increase cell size (hypertrophy), IGF-1 LR3 is researched for its ability to induce the division and creation of new muscle cells.
• Nitrogen Retention: Activation leads to a global shift in cellular behavior, promoting significant nitrogen uptake and protein accretion.
• Insulin Sensitivity: It mimics many of the effects of insulin, facilitating nutrient transport into cells independently of the standard insulin pathway.

Primary Research Applications

1. Sarcopenia and Muscle Wasting Research

IGF-1 LR3 is heavily utilized in studies involving age-related muscle loss and cachexia. Because it stimulates the proliferation of satellite cells, it provides a unique framework for investigating how to restore lean mass in degenerative disease models.

2. Hyperplastic Skeletal Muscle Adaptation

Known in research circles as the premier agent for studying "cell splitting," IGF-1 LR3 is used to observe how tissues adapt to perceived growth stress. Investigators study changes in myoblast fusion and the increase in mitochondrial density within newly formed fibers.

3. Oncology and Proliferation Control

In cancer research, IGF-1 LR3 is studied to understand the "over-activation" of growth pathways. By providing a stable IGF stimulus, research models can examine how specific inhibitors might halt the progression of IGF-sensitive tumor cells.

Form and Analytical Testing

At Dragon Pharma, the commitment to scientific accuracy begins with a rigorous manufacturing process. IGF-1 LR3 1mg is produced under strict laboratory conditions to ensure that the protein remains properly folded and bioactive.

• Lyophilization for Stability: The compound is supplied in a lyophilized (freeze-dried) form. This process removes moisture while preserving the complex tertiary structure, ensuring it arrives at your facility in optimal condition.
• Rigorous Analytical Verification: To guarantee a purity level of 99% or higher, every batch undergoes High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to verify that the molecular weight and purity profile are accurate.

Product Usage Disclaimer: This product is intended for laboratory and in-vitro research use only. It is not approved for human or veterinary application. Must be handled by qualified professionals. Not for drug, food, or cosmetic purposes. Misuse or misbranding is strictly prohibited.

Author:

All information was searched/edited by Dr. S. Edwin, and Dr. E. Croft who holds a doctorate from Case Western Reserve University School of Medicine