KISSPEPTIN 10mg

Note: Peptides will arrive in a powder form for maximum stability!!!

Kisspeptin-10 (10mg) is a specialized research peptide utilized primarily to investigate the neuroendocrine regulation of the reproductive axis and the initiation of GnRH signaling. As a potent endogenous ligand for the G protein-coupled receptor KISS1R, it is a fundamental regulator of puberty and fertility. Dragon Pharma provides Kisspeptin-10 10mg at a purity level of 99%+, specifically for use in in-vitro laboratory experiments and preclinical animal models.

Overview

In the realm of reproductive endocrinology and developmental biology, Kisspeptin-10 has become a fundamental tool for investigators exploring the "gatekeeper" of the reproductive system. Known scientifically as a truncated, highly bioactive fragment of the parent KISS1 protein, this decapeptide is the primary trigger for the release of Gonadotropin-Releasing Hormone (GnRH). Dragon Pharma provides Kisspeptin-10 10mg at a minimum purity of 99%, ensuring that researchers have access to a high-grade Research Peptide capable of producing reproducible and accurate data in complex biological models.

As scientific inquiry into hypothalamic-pituitary-gonadal (HPG) axis disorders, oncology, and metastatic suppression expands, the need for reliable KISS1R agonists like Kisspeptin-10 has grown. This expanded profile examines the biochemical characteristics, structural integrity, and multifaceted research applications of Kisspeptin-10 10mg.

Molecular Characteristics and Chemical Profile

The structural integrity of Kisspeptin-10 is optimized for high-affinity binding to the Kisspeptin receptor. Despite being a shorter fragment of the 145-amino acid KISS1 precursor, the decapeptide retains full biological activity at the receptor level.

• Chemical Identity: Kisspeptin-10 (KISS1-10)
• Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
• Molecular Formula: C63H83N17O14
• Molecular Weight: 1302.48 g/mol
• Purity: >99% (HPLC and Mass Spectrometry verified)
• Form: Lyophilized powder
• Manufacturer: Dragon Pharma

Source: PubChem

Research Applications

The peptide is utilized in various scientific investigative domains, including:

• HPG Axis Regulation: Mapping the neuroendocrine pathways that control the release of LH and FSH.
• Pubertal Initiation: Investigating the triggers for hypothalamic maturation in developmental models.
• Oncology & Metastasis: Studying the role of Kisspeptin as a metastasis suppressor in breast and prostate cancer research.
• Reproductive Biology: Researching the regulation of spermatozoa motility and follicular development.
• Vascular Biology: Evaluating the impact of KISS1 signaling on vasoconstriction and placental development.

Source: ScienceDirect

Pathway and Mechanistic Context

The core value of Kisspeptin-10 10mg in a laboratory setting is its ability to manipulate the GnRH pulse generator. In a natural physiological state, Kisspeptin neurons in the arcuate nucleus integrate signals from sex steroids and metabolic markers to control the reproductive cycle.

The KISS1R Signaling Axis

Upon activation by Kisspeptin-10, the KISS1R (GPR54) triggers a $G_{q/11}$ signaling cascade. This leads to the activation of phospholipase C and the subsequent mobilization of intracellular calcium, which stimulates the rapid secretion of GnRH into the hypophyseal portal system.

Key Mechanistic Shifts:

• Gonadotropin Stimulation: Kisspeptin-10 induces a potent, dose-dependent rise in Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH).
• Metastatic Suppression: In cancer research models, Kisspeptin-10 is studied for its ability to inhibit cell migration and invasion by modulating the cytoskeleton and focal adhesion.
• Metabolic Integration: Researchers use it to explore how nutritional status (via leptin) influences fertility through Kisspeptin-expressing neurons.

Primary Research Applications

1. Fertility and HPG Axis Research

Kisspeptin-10 is heavily utilized in studies involving hypogonadotropic hypogonadism and polycystic ovary syndrome (PCOS). Because it acts "upstream" of the pituitary, it provides a unique framework for investigating how to restore natural hormonal rhythms.

2. Puberty and Developmental Timing

Known in research circles as the "puberty switch," Kisspeptin-10 is used to observe how tissues adapt to the onset of reproductive maturation. Investigators study the epigenetic and environmental factors that accelerate or delay Kisspeptin signaling.

3. Oncology and Growth Regulation

In cancer research, Kisspeptin-10 is studied for its anti-metastatic effects. By activating KISS1R, research models examine how the peptide can induce "dormancy" in cancer cells and prevent the colonization of secondary organs.

Form and Analytical Testing

At Dragon Pharma, the commitment to scientific accuracy begins with a rigorous manufacturing process. Kisspeptin-10 10mg is produced under strict laboratory conditions to ensure stability and potency.

• Lyophilization for Stability: The compound is supplied in a lyophilized (freeze-dried) form. This process removes moisture while preserving the molecular structure, ensuring the peptide remains stable during transit.
• Rigorous Analytical Verification: To guarantee a purity level of 99% or higher, every batch undergoes High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to verify that the chemical signature matches the intended Kisspeptin profile.

Product Usage Disclaimer: This product is intended for laboratory and in-vitro research use only. It is not approved for human or veterinary application. Must be handled by qualified professionals. Not for drug, food, or cosmetic purposes. Misuse or misbranding is strictly prohibited.