Note: Peptides will arrive in a powder form for maximum stability!!!
NAD+ (Nicotinamide Adenine Dinucleotide) is a critical coenzyme and research reagent utilized primarily to investigate cellular bioenergetics, DNA repair, and mitochondrial signaling networks. As a central electron carrier in redox reactions, it is a fundamental cofactor for sirtuins and poly-ADP-ribose polymerases (PARPs). Dragon Pharma provides NAD+ 500mg at a purity level of 99%+, specifically for use in in-vitro laboratory experiments and preclinical animal models.
Overview
In the realm of metabolic research and cellular aging, few compounds offer as much utility as NAD+ (Nicotinamide Adenine Dinucleotide). This compound serves as a cornerstone for investigators exploring the bridge between nutrient sensing and epigenetic regulation. Dragon Pharma provides NAD+ 500mg at a minimum purity of 99%, ensuring that researchers have access to a high-grade Research Peptide and coenzyme capable of producing reproducible and accurate data in complex biological models.
As scientific inquiry into neurodegeneration, metabolic syndrome, and cellular longevity expands, the need for reliable NAD+ precursors and direct analogs has grown. This expanded profile examines the biochemical characteristics, structural integrity, and multifaceted research applications of NAD+ 500mg.
Molecular Characteristics and Chemical Profile
The structural integrity of NAD+ allows it to exist in two states: an oxidized form (NAD+) and a reduced form (NADH). This ratio is a primary marker of cellular health and metabolic efficiency in research environments.
- Chemical Identity: Nicotinamide Adenine Dinucleotide
- Molecular Formula: C21H27N7O14P2
- Molecular Weight: 663.43 g/mol
- Purity: >99% (HPLC and Mass Spectrometry verified)
- Form: Lyophilized powder
- Manufacturer: Dragon Pharma
Research Applications
The compound is utilized in various scientific investigative domains, including:
- Mitochondrial Bioenergetics: Mapping ATP production via the Electron Transport Chain (ETC).
- DNA Repair Mechanisms: Investigating PARP-mediated responses to genomic instability.
- Epigenetic Regulation: Studying sirtuin-linked histone deacetylation and gene silencing.
- Circadian Rhythm: Assessing the NAD+/SIRT1 axis in the regulation of biological clock genes.
- Neuroprotection: Evaluating the reduction of axonal degeneration and oxidative stress in neural models.
Pathway and Mechanistic Context
The core value of NAD+ 500mg in a laboratory setting is its ability to manipulate sirtuin activity and mitochondrial respiration. In a natural physiological state, NAD+ levels decline with age or metabolic stress, leading to compromised cellular repair.
The NAD+/Sirtuin Signaling Axis
Upon introduction to a research model, NAD+ serves as a mandatory substrate for SIRT1-7. These "longevity genes" initiate a global shift in cellular behavior, promoting stress resistance and mitochondrial biogenesis.
Key Mechanistic Shifts:
- Mitochondrial Efficiency: NAD+ activation facilitates the transfer of electrons in the mitochondria, optimizing the $ATP:ADP$ ratio.
- Genomic Stability: It acts as a substrate for PARP enzymes, which detect and initiate the repair of broken DNA strands.
- Autophagy: High NAD+ availability promotes cellular "recycling" pathways, helping to clear damaged proteins and organelles.
Primary Research Applications
1. Longevity and Anti-Aging Research
NAD+ is heavily utilized in studies involving cellular senescence. Because it is a required cofactor for enzymes that protect the genome, it provides a unique framework for investigating how to restore youthful metabolic function in aged tissue models.
2. Neurodegenerative Disease Models
Known in research circles for its neuro-restorative potential, NAD+ is used to observe how neurons adapt to perceived toxic strain. Investigators study changes in mitochondrial health in models of Alzheimer's and Parkinson's to see if elevating NAD+ levels can halt disease progression.
3. Metabolic Homeostasis and Obesity
In metabolic research, NAD+ is studied for its role in fat oxidation. By activating SIRT1 and PGC-1$\alpha$, research models examine how NAD+ can mimic the metabolic benefits of caloric restriction and endurance exercise.
Form and Analytical Testing
At Dragon Pharma, the commitment to scientific accuracy begins with a rigorous manufacturing process. NAD+ 500mg is produced under strict laboratory conditions to ensure that the coenzyme remains bioactive and stable.
- Lyophilization for Stability: The compound is supplied in a lyophilized (freeze-dried) form. This process removes moisture while preserving the delicate dinucleotide structure, ensuring it arrives at your facility in optimal condition.
- Rigorous Analytical Verification: To guarantee a purity level of 99% or higher, every batch undergoes High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to confirm that the chemical signature matches the intended profile.
Product Usage Disclaimer: This product is intended for laboratory and in-vitro research use only. It is not approved for human or veterinary application. Must be handled by qualified professionals. Not for drug, food, or cosmetic purposes. Misuse or misbranding is strictly prohibited.
Author:
All information was searched/edited by Dr. S. Edwin, and Dr. E. Croft who holds a doctorate from Case Western Reserve University School of Medicine
Refference:
Storage, Handling, and Reconstitution
For the best results in your research, proper handling of Dragon Pharma NAD+ is essential:
- Storage: Lyophilized vials should be stored at -20°C for long-term stability.
- Reconstitution: Use sterile, bacteriostatic water or physiological saline. Gentle agitation (swirling) is recommended; avoid vigorous shaking to maintain molecular integrity.
- Shelf Life: Once reconstituted, the solution should be refrigerated at 2°C to 8°C and utilized within 7 to 14 days to ensure maximum potency.
