SS-31 50mg

for: Mitochondrial Protection & Anti-Aging.

SS-31 (Elamipretide) is a specialized research reagent utilized primarily to investigate mitochondrial bioenergetics, oxidative stress modulation, and the structural integrity of the inner mitochondrial membrane. As a cell-permeable tetrapeptide, it is a potent stabilizer of cardiolipin, a phospholipid essential for mitochondrial cristae formation. Dragon Pharma provides SS-31 50mg at a purity level of 99%+, specifically for use in in-vitro laboratory experiments and preclinical animal models.

Overview

In the realm of mitochondrial research and cellular energetics, few compounds offer as much utility as SS-31 (D-Arg-2',6'-Dmt-Lys-Phe-NH2). Known scientifically as Elamipretide, this compound has become a fundamental tool for investigators exploring the prevention of mitochondrial dysfunction. Dragon Pharma provides SS-31 50mg at a minimum purity of 99%, ensuring that researchers have access to a high-grade Research Peptide capable of producing reproducible and accurate data in complex biological models.

As scientific inquiry into neurodegenerative diseases, heart failure, and acute kidney injury expands, the need for mitochondria-targeted antioxidants like SS-31 has grown. This expanded profile examines the biochemical characteristics, structural integrity, and multifaceted research applications of SS-31 50mg.

Molecular Characteristics and Chemical Profile

The structural integrity of SS-31 allows it to pass through the cell membrane and localize specifically within the inner mitochondrial membrane (IMM). Its unique alternating aromatic-cationic motif is what facilitates its high affinity for cardiolipin.

• Chemical Identity: SS-31 (Elamipretide)
• Sequence: D-Arg-Dmt-Lys-Phe-NH2
• Molecular Formula: C32H49N9O5
• Molecular Weight: 639.8 g/mol
• Purity: >99% (HPLC and Mass Spectrometry verified)
• Form: Lyophilized powder
• Manufacturer: Dragon Pharma

Research Applications

The peptide is utilized in various scientific investigative domains, including:

• Mitochondrial Bioenergetics: Mapping ATP production and electron transport chain (ETC) efficiency.
• Oxidative Stress: Investigating the neutralization of reactive oxygen species (ROS) at their primary source.
• Cardiolipin Dynamics: Studying the stabilization of the inner mitochondrial membrane structure.
• Neuroprotection: Assessing the reduction of mitochondrial fragmentation in models of Alzheimer's and Parkinson's.
• Ischemia-Reperfusion: Evaluating tissue resilience following oxygen deprivation events.

Pathway and Mechanistic Context

The core value of SS-31 50mg in a laboratory setting is its ability to manipulate mitochondrial efficiency without changing the actual membrane potential. In a natural physiological state, oxidative stress can damage cardiolipin, leading to a collapse of the mitochondrial cristae. SS-31 bypasses this degradation by binding to cardiolipin and shielding it from peroxidation.

The Cardiolipin-ETC Axis

Upon localization in the mitochondria, SS-31 initiates a shift in cellular resilience. It promotes the organized assembly of the electron transport chain complexes (supercomplexes), which simultaneously optimizes energy production and reduces electron "leakage."

Key Mechanistic Shifts:

• ATP Optimization: SS-31 facilitates a more efficient flow of electrons, enhancing the $ATP:ADP$ ratio in stressed cells.
• ROS Suppression: It inhibits the production of superoxide by stabilizing the relationship between cardiolipin and cytochrome c.
• Structural Preservation: By maintaining cristae curvature, SS-31 prevents the release of pro-apoptotic factors into the cytoplasm.

Primary Research Applications

1. Cardiovascular and Heart Failure Research

SS-31 is heavily utilized in studies involving myocardial infarction and chronic heart failure. Because it improves the energy output of cardiac myocytes, it provides a unique framework for investigating how to restore contractile function in failing heart tissue.

2. Nephrology and Acute Kidney Injury (AKI)

Known in research circles for its "nephroprotective" potential, SS-31 is used to observe how renal tubular cells adapt to perceived ischemic strain. Investigators study changes in mitochondrial morphology and the prevention of tubular necrosis.

3. Neurodegeneration and Aging

In brain research, SS-31 is studied for its ability to halt "mitophagy" and synaptic loss. Research models focusing on cognitive decline examine how SS-31 engagement can reduce the accumulation of amyloid-beta-induced mitochondrial stress.

Form and Analytical Testing

At Dragon Pharma, the commitment to scientific accuracy begins with a rigorous manufacturing process. SS-31 50mg is produced under strict laboratory conditions to ensure the compound remains stable and potent.

• Lyophilization for Stability: The compound is supplied in a lyophilized (freeze-dried) form. This process removes moisture while preserving the molecular structure, ensuring it arrives at your facility in optimal condition.
• Rigorous Analytical Verification: To guarantee a purity level of 99% or higher, every batch undergoes High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to confirm that the chemical signature matches the intended Elamipretide profile.

Product Usage Disclaimer: This product is intended for laboratory and in-vitro research use only. It is not approved for human or veterinary application. Must be handled by qualified professionals. Not for drug, food, or cosmetic purposes. Misuse or misbranding is strictly prohibited.

Author:

All information was searched/edited by Dr. S. Edwin, and Dr. E. Croft who holds a doctorate from Case Western Reserve University School of Medicine

Refference:

• image source: https://peptidesociety.org/_template-monographs-8/